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Search for "fluorinated substituents" in Full Text gives 7 result(s) in Beilstein Journal of Organic Chemistry.
Access to cyclopropanes with geminal trifluoromethyl and difluoromethylphosphonate groups
Beilstein J. Org. Chem. 2023, 19, 541–549, doi:10.3762/bjoc.19.39
- alkenes. We believe that the synergism of both fluorinated substituents could open new synthetic possibilities in the field of fluorinated organic materials. Results and Discussion We began our studies by preparing the fluorinated carbene precursor, diethyl 2-diazo-1,1,3,3,3-pentafluoropropylphosphonate
Redox-active molecules as organocatalysts for selective oxidative transformations – an unperceived organocatalysis field
Beilstein J. Org. Chem. 2022, 18, 1672–1695, doi:10.3762/bjoc.18.179
- processes [132][133][134]. Fluorinated substituents in the ketone molecule are used to achieve higher electrophilicity and reactivity. Both radical and ionic mechanisms were reported for CH-functionalization reactions [134][135]. An example of an oxidative hydroxylation involving aliphatic C(sp3)–H bonds is
Pauson–Khand reaction of fluorinated compounds
Beilstein J. Org. Chem. 2020, 16, 1662–1682, doi:10.3762/bjoc.16.138
- through treatment of 49a with trifluoromethanesulfonic acid in the presence of anisole to form 51. In a recent report, Fustero and co-workers synthesized a series of N-tethered 1,7-enynes 53 bearing fluorinated substituents starting from fluorinated tert-butanesulfinyl imines 52 (Scheme 27), which were
Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif
Beilstein J. Org. Chem. 2019, 15, 1441–1447, doi:10.3762/bjoc.15.144
- discovery chemistry. It is however, significantly less lipophilic than aryl-SCF3 which may offer a practical advantage in tuning overall pharmacokinetic profiles of molecules in development. Keywords: Cunninghamella elegans; cytochrome P450; fluorinated substituents; organofluorine metabolism
- ; sulfoxidation; Introduction Fluorine and fluorinated substituents are routinely used to modify the properties of lead compounds in medicinal chemistry and in bioactive discovery programmes [1][2]. To this end, aryl–F and aryl–CF3 are the most common modifications found in compounds registered in the patent
Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides
Beilstein J. Org. Chem. 2018, 14, 182–186, doi:10.3762/bjoc.14.12
- convenient route to fluorinated phthalides from 2-cyanobenzaldehyde or 2-formylbenzoates in a one-pot manner. In the transformations, installation of fluorinated substituents at the C3-position of phthalides has been achieved. The issue of the low stereoselectivity of the catalytic asymmetric
Electrophilic trifluoromethylselenolation of terminal alkynes with Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate
Beilstein J. Org. Chem. 2017, 13, 2626–2630, doi:10.3762/bjoc.13.260
- ][8][9][10][11][12][13][14][15]. In the objective to design new molecules with specific properties, novel fluorinated substituents have been developed, such as diverse trifluoromethylchalcogeno groups, due to their particular electronic properties [16] and, more especially, to their high lipophilicity
Organo-fluorine chemistry III
Beilstein J. Org. Chem. 2013, 9, 2180–2181, doi:10.3762/bjoc.9.255
- profile at present, particularly in methodology development. There has been considerable success across the international community in the development of organometallic methods for the incorporation of fluorinated substituents onto aryl and heterocyclic rings. Such motifs are required by the
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